COBRApy — метаболическое моделирование и FBA-анализ

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cobrapy is a Claude Code skill that performs constraint-based metabolic modeling using COBRApy (cobra 0.31.1) for genome-scale metabolic model analysis. It covers FBA, parsimonious pFBA, geometric FBA, flux variability analysis (FVA), and single or double gene and reaction knockout screens with multiprocessing support. Models can be loaded from bundled sources (e_coli_core, iJO1366, salmonella), remote BiGG and BioModels repositories, or local SBML, JSON, and YAML files. The default solver is GLPK via swiglpk; CPLEX, Gurobi, and a hybrid HIGHS/OSQP solver for large MILPs are optional. Designed for systems biology research and metabolic engineering, the skill handles cellular metabolism simulation, production envelope analysis, growth media design, and model consistency validation on Python 3.9+.