DepMap — анализ зависимостей раковых клеток от генов

★ 7.0 · research

depmap is a Claude Code skill that queries the Cancer Dependency Map (DepMap) — a Broad Institute resource — to retrieve CRISPR Chronos gene effect scores, drug sensitivity data from PRISM compound assays, and genetic dependency profiles across hundreds of cancer cell lines. It supports both the DepMap REST API and local analysis of downloaded files such as CRISPRGeneEffect.csv and sample_info.csv, with built-in helpers for filtering by Chronos thresholds (≤ −0.5 likely dependent, ≤ −1 strongly dependent), identifying cancer-selective vulnerabilities, uncovering synthetic lethal interactions, and running co-essentiality correlation analyses. Designed for oncology researchers and bioinformaticians who need to validate drug targets, stratify cell lines by lineage or mutation status, or discover biomarkers predicting sensitivity to gene knockout.